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美國System Biosciences
System Biosciences,簡稱SBI，美國加州灣區新成立的生技公司，致力于獨特、創新生物技術之開發，以研發利于基因及蛋白質功能鑒定、研究之嶄新方法和工具為宗旨。 現階段研發重心為RNA干擾（RNAi）研究之相關工具。
System Biosciences (SBI) 致力于開發獨特、革新的技術，為客戶研究蛋白組學和基因組學功能提供研究工具。SBI 是專業的慢病毒產品公司，提供基于慢病毒的所有相關產品、質粒、試劑盒及相關配套試劑和慢病毒延伸產品如IPS細胞多功能性誘導試劑盒和RNAi篩選文庫。
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System Biosciences continues to create new and unique products as well as improve our well-established product lines. Our commitment to providing leading-edge technologies is matched by our high quality of manufacturing and quality control for all of our research reagents and research project services.

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What to be looking for in 2009:
Here is a glimpse of new products on the near horizon.
New miRZips?: Novel lentivector-based technologies to permanently knockdown MicroRNAs.
Dual marker shRNA expression vector: SBI will release a new and powerful shRNA expression lentivector pGreenPuro? to enable both GFP and Puro marker selection of stably transduced cells for your RNAi experiments.
Sterol response pGreenFire? lenti-reporters: Lentivector-based transcription reporters for the monitoring of transcriptional network activity associated with sterol-sensing transcription factors - key to cardiovascular disease pathways.
Inducible expression lentivectors: New constructs will allow for the "on-demand" expression of cDNAs, shRNAs and microRNAs.
New and unique products for 2007–2008

New miR-SNaREs: MicroRNA Small Non-coding RNA Enrichment Systems that use epitope-tagged microRNA processing factors to pull-down the proteins and their associated RNAs. Identify messenger RNAs driven to RISC complexes.
New GeneNet? Focused shRNA Libraries: These focused shRNA Libraries encode a pooled set of shRNAs designed against all genes of a speciic function or class for Human Kinases, Phosphatases or Apoptosis-related genes. These libraries enable targeted high-throughput RNAi screens.
New miRNome MicroRNA Profilers: The qPCR arrays include microRNA assays in pre-formatted plates for either the full compliment of human or the full compliment of mouse individual microRNAs with three endogenous reference RNA controls on each plate. All microRNA assays based on the Sanger miRBase microRNA database registered entries.
New Lenti-miR? MicroRNA Precursor Clones: Expanded microRNA precursor collection available in HIV-based Lentiviral Vectors. Over 580 individual microRNA precursor clones available arrayed or as pooled lentivirus for HT screens.
New Lentiviral-based Stem Cell Reporters: SBI’s growing list of lentivectors has been developed as the most effective way to deliver genetic constructs into virtually any cell types in vitro and in vivo. SBI has expanded our lentivector construct line into stem cell reporters. Create transgenic cell lines easily to monitor cellular differentiation using cell and pathway-specific promoters linked to GFP reporters.
QuantiMir? RT Kit: this new and popular technology allows for the real-time qPCR quantitation of hundreds of microRNAs simultaneously from a single cDNA synthesis. Design your own microRNA assays for innovative experimentation.
Cancer microRNA qPCR assay panel (The OncoMir Collection): preformatted microRNA assay panel to assess 95 microRNAs known to be involved in Cancer.
Stem Cell microRNA assay panel: profile 95 microRNAs involved in Stem Cell differentiation enabling the simultaneous monitoring of stem cell self-maintenance, hematopoiesis pathways and neural differentiation.

SBI’s well-established product lines

Full Spectrum? Complete messenger RNA Amplification Kit: utilize mRNA specific primers targeting the most common motifs in mRNA to provide unbiased, complete representation of entire mRNA transcripts (both the 5’ and 3’ ends).
GeneNet? siRNA Libraries: Genome-wide, ready-to-use, pre-packaged lentiviral libraries provide an exciting opportunity for the screening of gene functions associated with biological responses.
Interferon Response Detection Kit: distinguish between real RNA interference and stress-related cellular responses.
PathNet? Transcriptional Reporter Lentivectors: a unique method to create a wide range of stable reporter cell lines for the study of signaling pathways.

We are grateful for your support in the past and look forward to providing you with the best new reagents, technologies and services to accelerate your successful research objectives.